Ray Peat on Aspirin

 

Diet Adjustments Required by Various Medications – Including Estrogen

“Every medication changes your nutrient needs. Tobacco, iron, aspirin, estrogen, sedatives, and diuretics must be considered. There are special diets for specific needs.”

– Nutrition For Women

Standard Treatment of Atrial Fibrillation versus Thermogenic Substances

“The standard treatment for atrial fibrillation involves destroying part of the heart’s conduction system, called ablation, which costs more than $25,000 in the USA and leads to heart failure in a very high percentage of cases. Correcting the problematic prolonged QT interval with thermogenic substances like progesterone, thyroid hormone, and aspirin (Korkmaz-Içez et al., 2016) is of no interest to the medical profession.”

– November 2020 – Ray Peats Newsletter

The Role of Aspirin in Mitochondrial Oxygen Consumption and Fever

“Probably due to Aspirin’s fever-reducing effect, medical culture tends to view it as antithermogenic, despite its known stimulating effect on mitochondrial oxygen consumption. Like thyroid hormone, Aspirin prevents the stress-induced loss of sodium, which is an important part of our temperature and energy regulation system.”

– November 2020 – Ray Peats Newsletter

Compounds That Reduce Carbon Monoxide or Mitigate Its Harmful Effects

“Safe substances that reduce carbon monoxide or protect against its effects include methylene blue, caffeine, aspirin, progesterone, and red light.”

– November 2017 – Ray Peats Newsletter

Anti-inflammatory Treatments in Response to the New Coronavirus

“In response to the new coronavirus, some groups reacted quickly and successfully treated with anti-inflammatory substances – Losartan, Cinanserin (a serotonin antagonist), Aspirin, as well as Azithromycin or Erythromycin, which lower intracellular calcium levels. The effects of Aspirin overlap with those of Losartan, and it downregulates the angiotensin receptor ATR1.”

– May 2020 – Ray Peats Newsletter

Factors for Healthier Pregnancies and Life After Birth

"The most important factors that can be optimized with existing resources. Healthier pregnancies lead to a healthier and happier life after birth. These factors include sunlight, vitamin D, milk, cheese, eggs, fruits, and well-cooked vegetables, fiber-rich foods, as well as optimizing thyroid function, pregnenolone, and progesterone (which support mitochondrial function and protect against aldosterone, parathyroid hormone, excess serotonin, CRH, and cortisol, and also increase allopregnanolone), along with the use of the safest anti-inflammatory and antiserotonergic medications like aspirin and cyproheptadine when needed."

– May 2019 – Ray Peats Newsletter

Oxidative Processes and Factors of Enzyme Regulation

"The oxidative processes that support the targeted, creative functioning of the organism optimize CO₂ by inhibiting carbonic anhydrase; this enzyme is inhibited by the thyroid hormone T3, progesterone, urea, caffeine, antipsychotics, and aspirin. Substances that tend to cause a return to primitive anaerobic energy production activate the enzyme – for example serotonin, tryptophan, cysteine, histamine, estrogen, aldosterone, HIF, SSRIs, angiotensin, and parathyroid hormone."

– March 2020 – Ray Peats Newsletter

Fundamental Substance Combinations Instead of Disease-Specific Medications

"Combinations of substances like CO₂, progesterone, angiotensin receptor blockers, acetazolamide, and aspirin, which affect fundamental properties of the organism, are suitable for a wide range of problems currently treated with drugs considered specific to certain diseases. The goal should be to support the patient's recovery, not to eliminate a disease."

– March 2020 – Ray Peats Newsletter

Aspirin and Progesterone for Treating Insomnia

"Taking aspirin before bedtime to inhibit prostaglandin synthesis is likely helpful for age-related insomnia. Progesterone and vitamin E work in different ways to prevent excessive stimulation by prostaglandins."

– March 2018 – Ray Peats Newsletter

Neuroprotective effects of caffeine, aspirin, and melatonin

“Caffeine, aspirin, and melatonin protect the substantia nigra from rotenone.”

– March 2017 – Ray Peats Newsletter

Protective factors in Parkinson’s generally counteract estrogen

“Substances that likely protect against Parkinson’s disease generally act against estrogen and inflammatory-degenerative processes: progesterone, minocycline and other anti-inflammatory antibiotics, agmatine, aspirin, coffee, niacinamide, citrus flavonoids, vitamin D, ACE inhibitors, as well as fiber-rich and antiseptic foods.”

– March 2017 – Ray Peats Newsletter

List of various medications and supplements

“Acetazolamide, agmatine, amantadine, aminoguanidine, antibiotics (minocycline, tetracycline, etc.), antihistamines, aspirin, bromocriptine, DCA, emodin, glucagon, glucose, memantine, methylene blue, niacinamide, T3 (triiodothyronine), vitamin D, vitamin E.”

– March 2016 – Ray Peats Newsletter

Measures to mitigate the harmful effects of excess serotonin

“Avoiding prolonged fasting and strenuous exercise that increase free fatty acids, combining sugar and proteins to keep free fatty acids low, and using aspirin, niacinamide, or cyproheptadine to reduce free fatty acid formation caused by unavoidable stress, avoiding an excess of phosphate relative to calcium in the diet, consuming milk and other anti-stress foods before bedtime or during the night, as well as a brightly lit environment during the day with regular sun exposure can minimize the harmful effects of excessive serotonin and reduce the associated inflammation, fibrosis, and atrophy.”

– July 2019 – Ray Peats Newsletter

The controversy surrounding aspirin in medical fields

“Aspirin is just one of many cheap generic substances that have often been criticized in medical journals.”

– July 2018 – Ray Peats Newsletter

Aspirin and Inflammation: The Lesser-Known Pro-Oxidant Effect

“The fact that the inflammation-promoting enzymes aromatase, cyclooxygenase, and nitric oxide synthase, which are inhibited by an oxidizing environment, are also inhibited by aspirin would strongly suggest that aspirin and salicylic acid act as pro-oxidants.”

– July 2016 – Ray Peats Newsletter

Counteracting Oxidative Damage with Aspirin and Bioflavonoids

“Oxidative damage, such as lipid peroxidation, is a seriously harmful phenomenon. Aspirin and bioflavonoids provide strong protection against lipid peroxidation as well as DNA mutations and protein damage caused by the most toxic free radical, the hydroxyl radical.”

– July 2016 – Ray Peats Newsletter

Dietary Defense Mechanisms Against Nitric Oxide

“The main defenses against nitric oxide include progesterone, vitamin E, vitamin K, vitamin A, niacinamide, caffeine, aspirin, as well as foods containing flavonoids, terpenoids, polyphenols, and sterols. Pasture milk contains a variety of polyphenols. Citrus fruits, many tropical fruits (e.g., guavas, longans, and lychees), and cooked mushrooms are good sources of apigenin, naringenin, and related compounds.”

– January 2016 – Ray Peats Newsletter

Increased Vitamin K Requirement Due to Aspirin

“Aspirin increases your need for vitamin K, even if you don’t use much of it. People who use aspirin for arthritis or cancer often take several grams per day.”

– Email Response from Ray Peat

Germ-Killing Properties of Aspirin

“Aspirin has a mild germ-killing effect.”

– Email Response from Ray Peat

Reducing Stomach Reactions from Aspirin

“I don’t know anyone who has a stomach reaction when they dissolve aspirin in hot water and then take it with food.”

– Email Response from Ray Peat

Prostaglandins in Cancer and the Therapeutic Potential of Aspirin

“Prostaglandins were discovered in prostate fluid, where they occur in significant concentrations. They are so deeply involved in the development of all types of cancer that aspirin and other prostaglandin inhibitors should be considered a fundamental part of cancer therapy.”

– 1998 – May – Ray Peats Newsletter
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